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Read our disclaimer for details. Results First Posted : October 31, Last Update Posted : October 31, Study Description. The purpose of this study is to compare brolucizumab RTH ophthalmic solution for intravitreal IVT injection 6 mg to aflibercept ophthalmic solution for IVT injection 2 mg in subjects with untreated active choroidal neovascularization CNV secondary to age-related macular degeneration AMD in the study eye. Drug Information available for: Aflibercept Ziv-aflibercept.
FDA Resources. Arms and Interventions. Single IVT injection of aflibercept ophthalmic solution at Day 0, Week 4, and Week 8, followed by q8w maintenance regimen until study exit. Outcome Measures. Positive q12 treatment status was defined as IVT injections per planned dosing regimen one injection every 12 weeks "q12w", after the initial three loading injections every 4 weeks "q4w". BCVA with spectacles or other visual corrective devices was assessed using ETDRS testing at 4 meters and reported in letters read correctly letters.
CSFT the average retinal thickness of the circular area within 1 millimeter diameter around the foveal center was assessed using Spectral-Domain Optical Coherence Tomography SD-OCT , a non-invasive measurement which produces cross-sectional and 3-dimensional images of the eye. CSFT the average retinal thickness of the circular area within 1 millimeter diameter around the foveal center was assessed using SD-OCT, a non-invasive measurement which produces cross-sectional and 3-dimensional images of the eye. CNV lesion size the area of new blood vessels in the choroid layer of the retina size was measured using fluorescein angiography FA.
A disease activity assessment DAA was performed to identify q8 treatment need. Serum samples were collected and assessed for anti-drug antibody status. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.
More Information. Publications automatically indexed to this study by ClinicalTrials. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
Drug: Brolucizumab ophthalmic solution Drug: Aflibercept ophthalmic solution. Phase 3. Study Type :. Actual Enrollment :. Harriers have a playful, outgoing personality. They are not quite as outgoing as the Beagle , but they definitely love to be around people and other animals. They generally are sweet-tempered and tolerant of children. You should watch them, however, around pets that aren't dogs.
Because they are pack dogs, they generally get along well with other dogs, but may see cats, hamsters, and other non-canine pets as prey. They like to live in a pack, whether the pack is made up of other dogs or people. You should always keep in mind that your Harrier is an active dog who likes to explore and track. Some like to bay a loud, prolonged bark.
You should have a well-secured fence your dog can't jump over or crawl under, and when you take your Harrier to unsecured areas, such as a park, be sure to keep him on leash. Otherwise, he may take off, chasing a squirrel or a rabbit. Also, remember that Harriers were bred to have a lot of energy and stamina, as well as to think for themselves. They are independent and tireless hunters. These traits, while good for hunting, may present difficulties in training.
You'll need to provide them with enough exercise to keep them from becoming bored and destructive. These are dogs who love to be with you, but do not demand attention. They are capable of entertaining themselves. Your job is to make sure that their idea of entertainment doesn't mean getting into mischief!
Because they are independent thinkers who can sometimes be stubborn, you should strongly consider obedience training for your Harrier.
Because these dogs have great stamina and are energetic without being hyperactive, they do well in performance sports such as agility and rally. They also make great jogging, bicycling, and hiking companions. Although they are relatively inactive in the house, they are not recommended for apartment dwellers unless you are willing to provide them with a great deal of outside exercise every day. Harriers make good watchdogs because they will alert you to any strange noises or visitors to your home.
However, don't expect them to be guard dogs. They are so friendly that they often greet strangers as though they were old friends. Although they are sweet, even-tempered dogs, Harriers are not recommended for first-time dog owners because of their training and exercise needs. There are several conflicting stories about how the Harrier breed came to be.
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The word Harrier was Norman French and meant hound or dog. With that connection, the best guess may be that the earliest Harrier-type dogs descended from a cross of Bloodhounds, Talbot hounds, and perhaps even Basset Hounds, all of which had their origins in what are now France and Belgium.
The Penistone pack, established by Sir Elias Midhope, existed for at least years, well into the 18th century. Originally, these packs were used to hunt hare with the hunters following on foot, so at that time, they were a much slower and more methodical type of hound than today's Harriers.
When foxhunting became fashionable with the hunters on horses, Harriers were adapted to have more speed. At that time, Harriers were much more popular than Beagles. Admission into the Stud Book in those days was based on the records of the pack owner or by committee. It appears that many of the foundation Harriers were in fact small Foxhounds. Additionally the names of some of these foundation Harriers appear in the pedigrees of top-winning Beagles.
From this, it's surmised that the name "Harrier" was used to describe the type of hunting and size of the hound rather than its pedigree. The reason for this could be that in England, Harriers are only owned by hunting organizations and are registered with the Association of Masters of Harriers and Beagles. They usually are registered with the AMHB only if they are a member of a pack and have been used for at least one hunting season.
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There are reports of Harriers being imported to the U. Several packs of Harriers were established and some were recognized by the Masters of Foxhounds Association of America. Although they are great family companions, Harriers have never been a popular breed. From to , only Harriers have been registered with the American Kennel Club. Although they've always ranked at or near the bottom of the list in popularity, Harriers have become AKC Champions of Record, which is a very high percentage of champions to dogs registered.
Despite their lack of popularity, they have been a part of the American Kennel Club since its beginnings, being the 13th breed recognized by the AKC, and the 4th Hound breed recognized. Four Harriers from New York were entered in the second Westminster show. Registrations of Harriers were few and far between in the early s. Monarch was owned by the Monmouth County Hunt, and bred from dogs imported from England.
There were several Harrier packs in the US through the early years of the 20th Century. George S. Patton , who was at the time a Colonel, was Master of the Cobbler Harriers from to As in England, most Harriers in the U. A few Harriers started being shown in AKC shows in the early s. While most Harriers in the U. Harriers are medium-size dogs. They stand between 19 and 21 inches tall and weigh 45 to 60 pounds.
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He's also a typical hound in that he's an independent thinker and can be stubborn. It's important to train him using methods that will persuade him that being obedient is his idea. He's a good watchdog and will alert you to strange sounds or the approach of people. If you're not home, he'll watch the burglar come in and cart off your silver.
Socialization helps ensure that your Harrier puppy grows up to be a well-rounded dog.
Harriers are generally healthy, but like all breeds, they're prone to certain health conditions. Not all Harriers will get any or all of these diseases, but it's important to be aware of them if you're considering this breed.